Circ-NOLC1 promotes epithelial ovarian cancer tumorigenesis and progression by binding ESRP1 and modulating CDK1 and RhoA expression

Abstract Circular RNAs (circRNAs) play important roles in cancer tumorigenesis and progression, representing prognostic biomarkers therapeutic targets. In this case, we demonstrated the role of circ-NOLC1 epithelial ovarian (EOC). Our results have shown that Circ-NOLC1 expression was higher EOC tissues than normal tissues, positively associated with FIGO stage, differentiation. Among cell lines, highest A2780, lowest CAOV3. Overexpression CAOV3 cells increased proliferation, migration, invasion ability, whereas silencing A2780 had opposite effect: however, neither downregulation nor overexpression influenced NOLC1 mRNA expression. nude mice subcutaneous tumors, decreased tumor growth. Bioinformatic analysis RNA-binding protein immunoprecipitation showed could bind to ESRP1. addition, significantly ESRP1, RhoA, CDK1 level; effects. The tumor-promoting effect inhibited by knockdown CDK1, or RhoA -overexpressing cells, which might act modulating conclusion, our study promote development binding ESRP1